IARC Scientific Publications related to IARC Monographs Evaluations

IARC Scientific Publications No. 147
Species Differences in Thyroid, Kidney and Urinary Bladder Carcinogenesis

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Ordering Information
Edited by C.C. Capen, E. Dybing, J.M. Rice and J.D. Wilbourn
225 pages
ISBN 92 832 2147 8
US$ 20

In November 1997 an expert group was convened to discuss available knowledge on the epidemiology, pathology and mechanisms related to certain tumours that are commonly seen in assays for carcinogenicity in rodents in order that their importance in human hazard evaluation might be assessed.
The tumours of interest were urinary bladder carcinomas associated with urolithiasis, microcrystalluria and cettain urinary precipitates; renal cortical tumours in male rats associated with alpha -2 urinary globulin nephropathy; and thyroid follicular-cell tumours associated with imbalances in thyroid stimulating hormone. Included in the book are a series of individually authored papers on these various topics, as well as a Concensus Report including consideration of how such data may be used within the evaluation process in the IARC Monographs on the Evaluation of Carcinogenic Risks to Humans.