IARC Scientific Publications related to IARC Monographs Evaluations

IARC Scientific Publications No. 140

Mechanisms of Fibre Carcinogenesis


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Ordering Information
  Edited by A.B. Kane, P. Boffetta, R. Saracci and J.D. Wilbourn
1996
135 pages
ISBN 92 832 2140 0
US$ 25

Several types of mineral fibres, such as asbestos and erionite, are known to pose a carcinogenic hazard to humans. For several other fibre types the evidence is less clear. The integration of results from human and experimental studies is often a critical step in the process of assessing risk to humans, and an understanding of the mechanisms through which mineral fibres exert their carcinogenic activity is of major importance in this process.
This volume provides a thorough and up-to-date synthesis of the mechanisms of fibre carcinogenesis. A consensus document assesses the strengths, weaknesses and gaps in the data concerning fibre characterization and genotoxicity, fibre-related cell proliferation and activation, gene expression, animal models, mixed dust exposures and interactions with other carcinogens. The relevance of mechanistic data from in-vitro and in-vivo assays to the evaluation of fibre carcinogenicity is also discussed. Authored review papers, also published in this volume, provide the background material for much of the discussion.